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In 1839 the Annals of Chemistry, Volume 29, by Friedrich Woehler and
Justus von Liebig, stated that "Beer yeast, when dispersed in water,
breaks down into an infinite number of small spheres. If these spheres
are transferred into an aqueous solution of sugar, they develop into
small animals. They are endowed with a sort of suction trunk with which
they gulp the sugar from the solution. Digestion is immediate and
clearly recognizable because of the discharge of excrements. These
animals evacuate ethyl alcohol from their bowels and carbon dioxide
from their urinary organs. Thus one can observe how a specifically
lighter fluid is extruded from the anus and rises vertically, whereas a
stream of carbon dioxide is ejected at very short intervals from their
enormously large genitals."